Endocrine Abstracts

Background: Bone mineral density measurement sometimes reveals osteoporosis that is a consequence of undiagnosed or neglected long-standing health disorders. These secondary causes of osteoporosis should be carefully investigated, especially in men.Case Presentation: A 63-year-old male complained of back pain and was referred to endocrinology clinic due to a poor densitometry finding indicating osteoporosis. He presented with severe obesity (body mass in...

Introduction: It is a well-known fact that in Baltic Sea region there is low level of ecological selenium and iodine in soil and water, which can lead to subclinical hypo-activity of thyroid gland. By epidemiological data of that region, chronic stress and low insolation favour the decrease of metabolic rate, hypercholesterolemia and obesity in 30% of population.Method: In Dietological Centre of Jurmala, Latvia, 87 obese patients, in the age group of 25&...

The development of insulin resistance and type 2 diabetes mellitus (T2DM) in obesity involves (a) adipose inflammation, and (b) restricted adipose expansion with ectopic lipid deposition. Metalloproteinases (MPs) and tissue inhibitors of metalloproteinases (TIMPs) constitute a key regulatory system in inflammation and tissue remodelling. Evidence of MP and TIMP involvement in adipose tissue inflammation and modulation of adipose expansion is currently restricted to work in adi...

Introduction: High total cholesterol (tChol), LDL and trygliceride (TAG) level is independent risk factor for cardiovascular disease. High prevalence of malignant atherogenic profile is alarming in type 2 diabetics (high triglyceride, low HDL). It is very often that dislipidemia is associated with diabetes and obesity, as well as hypertension.Aim: The aim of this study is to analyse lipid profile in patients with type 2 diabetes in Kragujevac depending o...

Hyperlipidemia is common among patients with ST-elevation myocardial infarction (STEMI) and is associated with high risk of mortality and morbidity. Hypertriglyceridemia and low HDL cholstereol are independent risk factor for cardiovascular disease.Aim: The aim of this study is to analyse lipid profile in patients with STEMI with and without diabetes.Material and methods: This study included all patients registered in Coronary Unit...

Background: Obesity is the excessive accumulation of adipose tissue to the extent that health may be impaired. Determination of the mechanisms governing adipose deposition and body weight regulation are now a scientific priority. High dietary fat intake is generally considered to be a factor in obesity’s multi-factorial aetiology and the metabolic syndrome. Yet not all dietary fats appear to be obese genic to the same degree.Objective: To study the ...

Mildronate, a γ-butyrobetaine analogue is actually used as an antiischemic drug. It was also shown to have effect on mechanisms of glucose utilization.Methods: Diabetes mellitus in Wistar rats was induced by injection of streptozotocin (50 mg/kg). Experimental rats were treatment with Mildronate (100 mg/kg daily, per os) for 6 weeks. Weight, blood glucose concentration, blood triglyceride concentration, blood ketone body concentration, glycat...

Hyperglycaemia is one of the most common medical conditions women encounter during pregnancy. The occurrence of gestational diabetes mellitus (GDM) is rising and it represents an important modifiable risk factor for adverse pregnancy outcomes. Similar to GDM, excessive weight gain is associated with a number of undesirable consequences for both the mother and neonate. The aim of this study was to evaluate prevalence of GDM in outpatient practice and investigate associations be...

Background: In March 2020, at the beginning of the first COVID-19 lockdown, Zagreb (Croatia) was hit by a strong earthquake aftermore than 100 years.Restrictive epidemiological measures affected people’s lifestyles, and the earthquakewas an additional traumatic event.Objectives: Determine whether the earthquakes and the lockdown affected glycaemic control in type 1 diabetes patients using flash glucose monitoring (FGM).Metho...

Fat distribution influences metabolic risk. Accumulation of fat in the upper body increases metabolic risk, while lower body adipose expansion is protective. Oestrogen promotes lower body adiposity; transgender women on oestrogen therapy show increases in gluteal adipose, while transition to the menopause is associated with a shift in fat distribution towards the upper body, concurrent with changes in metabolic risk. Still, mechanisms governing the depot-specific effects of oe...